Analytical instruments · Designed and built in Winchester

Instruments for freeze-drying analysis

Our scientists designed these instruments for formulation work. We build, calibrate and certify them in Winchester and supply them worldwide.

Lyostat, Lyotherm and MicroPress instruments together

Freeze-drying microscope

Lyostat 5

Freeze-drying microscopy shows a formulation as it dries. Use it to identify collapse and eutectic melting.

Observe collapse, eutectic melting and crystallisation
Study how annealing affects ice crystals and solute structure
Capture digital video and measurements for cycle development

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Frozen-state analyser

Lyotherm 3

Differential thermal analysis and electrical impedance measurements reveal thermal events and changes in molecular mobility in frozen formulations.

Explore softening and glass-transition behaviour
Inform annealing and freezing steps
Complements the visual information from Lyostat

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Mechanical-property tester

MicroPress

Measure the mechanical strength of lyophilised cakes and lyobeads after drying.

Compare cake structure between formulations
Check batch-to-batch consistency
Assess robustness for handling and shipping

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Lyobead generator

LyobeadPRO

A benchtop system dispenses precise droplets into liquid nitrogen to form frozen beads for freeze-drying. Designed and developed under our ISO 13485 certification.

Up to 3,500 beads/h single tip, 7,200 beads/h dual tip
Bead volumes up to 50 µl with 0.10% volume precision
CV below 2% across low, medium and high viscosities
Rotating head segregates beads in the dewar to avoid aggregation

Data sheet (PDF) Enquire

How they fit together

Pre- and post-lyo

Lyotherm 3: Characterise the frozen state, including glass transitions and softening.
Lyostat 5: Watch the formulation dry and find its collapse temperature.
MicroPress: Measure the strength of the finished cake or bead.
LyobeadPRO: Produce uniform frozen beads for lyobead products.

Our CDMO laboratory also uses these instruments for analysis services.

CDMO laboratory